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For the variables included in the models, the variance inflation factor VIF is less than 5, and there is no evidence of collinearity between the independent variables. Whether this mechanism is the same in female mice is unclear; however, plasmacytoid DCs from females produce more type I interferons, and estrogen drives DC differentiation from bone marrow precursors , , suggesting that DCs may have a similar role. Rodent models of hypertension have also been associated with the upregulation of pathogenic Th17 cells and the downregulation of protective Tregs 1649 - Recent data demonstrated that females are at risk for cardiovascular disease at a lower np pressure BP level than males. Identify normotensive individuals with high normal BP who are going to develop hypertension in three-year follow-up and demonstrate differences according to their gender. Healthy young females have lower BP than males at a similar age but experience a steeper increase in BP from the third decade of life.

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